Annayya is about an elder brother who loves his two younger brothers and would do anything to see them happy. Rajaram (Chiranjeevi), owner of a fleet of lorries has two brothers Ravi (Ravi Teja) and Gopi (Venkat) who has a careless attitude towards life. When Rajaram approaches Devi (Soundarya) for her sisters' hand in marriage to his brothers, she refuses her consent on grounds that the two are wayward drunkards. Rajaram reacts sharply to it and vows to get his brothers married to her sisters. But things take an unexpected turn. Rest of the story is about how Rajaram helps his brothers indirectly to achieve their goals and become better persons.