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Lisa Edelstein (/ˈliːsə ˈɛdəlstiːn/; born May 21, 1966) is an American actress and playwright best known for playing Dr. Lisa Cuddy on the medical drama series House MD.
Edelstein was born in Boston, Massachusetts, the daughter of Bonnie and Alvin Edelstein. Her father is a pediatrician at Chilton Memorial Hospital (since retired). Her family is Jewish.The youngest of three children, she was raised in Wayne, New Jersey, and attended Wayne Valley High School, graduating in 1984.
After being dubbed a ""celebutante"" by The New York Times magazine during her club kid days Edelstein used her new-found celebrity to write, compose, and star in an original musical called Positive Me in response to the growing AIDS crisis of the 1980s. After a brief stint hosting Awake on the Wild Side for MTV in 1990, she spent the early 1990s appearing in guest roles on several popular comedies, including Mad About You, Wings, and The Larry Sanders Show. On Sports Night, she played a sports reporter who claimed to be a former lover of Josh Charles's character whom he did not remember. On Seinfeld, she played George Costanza's frustrated girlfriend, the ""Risotto Girl"" (the only girlfriend of George's to appear in multiple episodes other than Susan Ross).
Edelstein picketed during the 2007--08 Writers Guild of America strike, which halted the production of House.
Bigger roles in TV dramas soon followed, among them the lesbian sister on ABC's Relativity (1996); a high-priced call girl turned Rob Lowe's date on The West Wing (1999); an assigned male at birth (AMAB) transgender woman on Ally McBeal (2000); and Ben Covington's (Scott Speedman) girlfriend on Felicity (2001). She also continued to land guest star spots on such shows as ER, Frasier, Just Shoot Me!, Without a Trace, and Judging Amy.
The actress has lent her voice to several animated programs including King of the Hill, American Dad!, Superman: The Animated Series (as Mercy Graves, Lex Luthor's bodyguard, a role she later reprised in several episodes of Justice League) and the video game adaptation of Blade Runner (1997). Edelstein's film credits include small parts and cameos in What Women Want, Keeping the Faith, As Good as It Gets, and Daddy Day Care.
From 2004 to 2011, she played Dr. Lisa Cuddy, the Dean of Medicine at Princeton-Plainsboro Teaching Hospital and frequent character foil and ex-girlfriend to title character Gregory House (Hugh Laurie) on Fox's TV series House, M.D. In May 2011, Edelstein announced that she would not return for the eighth season of House.
Edelstein starred in the Lifetime network movie Special Delivery with Brenda Song. In June 2011, it was revealed that she would join the cast of The Good Wife for a ""juicy"" multi-episode arc. She played Celeste Serano, an attorney and one of Will Gardner's (Josh Charles) old flames, in an echo of the relationship between their Sports Night characters.
On July 10 2013, TVLine announced that Edelstein will join Season 6 of ABC series Castle for a multi-episode arc.
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Lisa Cuddy, M.D., is a fictional character on the Fox network medical drama House. She is portrayed by Lisa Edelstein. Cuddy was the Dean of Medicine and hospital administrator of the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. She also becomes House's love interest through the years to start a relationship with him in season seven. Cuddy quit her job after the events of season seven's finale ""Moving On"".
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Cuddy's role in House is that of Dean of Medicine and hospital administrator. She is 43 years old, Jewish, and has a mother and one sister; her father died. She began dreaming of becoming a doctor when she was 12, graduated from medical school at age 25 as second best in her class, and became the first female and second youngest Dean of Medicine ever at age 32. Cuddy attended the University of Michigan, where she first met Gregory House (Hugh Laurie, and with whom she shared a one-night stand. Years later, when House suffered an infarction in his right leg in the backstory, he was treated by Cuddy at Princeton-Plainsboro Teaching Hospital. Under Cuddy's care and on the order of his Medical Proxy, House's then girlfriend of five years Stacy Warner (Sela Ward), the dead muscle in his leg was removed against House's explicit wishes after he was put into an induced coma, leaving House with a permanent disability and chronic pain.